产品
编 号：F085349
分子式：C20H15N5O3S2
分子量：437.49
分子式：C20H15N5O3S2
分子量：437.49
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 1235397-05-3
产品详情
生物活性：
PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect.
体内研究：
PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors.Animal Model:6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)
Dosage:3, 30 mg/kg
Administration:I.p.
Result:Significantly reduced spontaneous pain behaviors in mice.
PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect.
体内研究：
PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors.Animal Model:6-8 weeks adult male C57BL/6J mice (OD1-induced spontaneous pain model)
Dosage:3, 30 mg/kg
Administration:I.p.
Result:Significantly reduced spontaneous pain behaviors in mice.
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