产品
编 号：F762940
分子式：C20H25N3O2
分子量：339.43
分子式：C20H25N3O2
分子量：339.43
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规格
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CAS No: 3023019-93-1
产品详情
生物活性：
KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research.
体内研究：
KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain.
体外研究：
KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes.
KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research.
体内研究：
KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain.
体外研究：
KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes.
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