产品
编 号：F762933
分子式：C46H49BN6O9
分子量：840.73
分子式：C46H49BN6O9
分子量：840.73
产品类型
规格
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结构图
CAS No: 3023438-33-4
产品详情
生物活性：
CypD-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypD-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypD-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.
体外研究：
CypD-IN-1 (C3A) has selectivity for CypD, CypA, CypB and CypE with Ki values of 0.52 μM, 1.8 μM, 5.6 μM and 0.072 μM, respectively.CypD-IN-1 has inhibitory activity for CypD, CypA, CypB, CypE, CypC and CypG with IC50 values of 0.6 μM, 3 μM, 4 μM, 0.013 μM, 17 μM and 40 μM, respectively.CypD-IN-1 has binding and inhibition potency for CypE K212A, K217A and K218A mutants with IC50 values of 0.03 μM, 2 μM and 0.019 μM, respectively.
CypD-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypD-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypD-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.
体外研究：
CypD-IN-1 (C3A) has selectivity for CypD, CypA, CypB and CypE with Ki values of 0.52 μM, 1.8 μM, 5.6 μM and 0.072 μM, respectively.CypD-IN-1 has inhibitory activity for CypD, CypA, CypB, CypE, CypC and CypG with IC50 values of 0.6 μM, 3 μM, 4 μM, 0.013 μM, 17 μM and 40 μM, respectively.CypD-IN-1 has binding and inhibition potency for CypE K212A, K217A and K218A mutants with IC50 values of 0.03 μM, 2 μM and 0.019 μM, respectively.
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