产品
编 号:F762915
分子式:C16H12Cl2N2O2S
分子量:367.25
产品类型
结构图
CAS No: 3029431-68-0
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产品详情
生物活性:
CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza.
体外研究:
CLK1-IN-2 (Compound 27a) has selectivity for Clk1 with an IC50 value of 1.7 nM.CLK1-IN-2 shows long metabolic half-lives of 6.4 h.CLK1-IN-2exhibits a GI50 of 3.4 μM in T24 cancer cells.CLK1-IN-2 shows a cellular Ki valiue of 0.051 μM in NanoBRET cellular Clk1 engagement assay.