产品
编 号：F762896
分子式：C25H30N4O8S
分子量：546.59
分子式：C25H30N4O8S
分子量：546.59
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 3027658-65-4
产品详情
生物活性：
M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity.
体内研究：
M1069 inhibits breast tumor (CD73hi/adenosine-rich 4T1 syngeneic) growth in vivo in mice and enhances chemotherapeutic agents efficacy.
体外研究：
Metabolically stressful conditions, including inflammation and cancer, induces extracellular concentrations of adenosine increase.M1069 dose-dependently suppresses 5’-N-ethylcarboxamide adenosine (stable analog of adenosine)-stimulated cyclic adenosine monophosphate (cAMP) and phosphorylated cAMP- response element binding protein (pCREB) induction, inhibits interleukin (IL)-2 production.M1069 suppresses vascular endothelial growth factor (VEGF) production from human macrophages in adenosine-rich settings.M1069 inhibits protumorigenic cytokine secretion, such as CXCL1, CXCL5 and granulocyte-colony stimulating factor, and reduces IL-12 secretion from adenosine-differentiated dendritic cells.M1069 enhances T-cells activation in adenosine-differentiated dendritic cells.
M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity.
体内研究：
M1069 inhibits breast tumor (CD73hi/adenosine-rich 4T1 syngeneic) growth in vivo in mice and enhances chemotherapeutic agents efficacy.
体外研究：
Metabolically stressful conditions, including inflammation and cancer, induces extracellular concentrations of adenosine increase.M1069 dose-dependently suppresses 5’-N-ethylcarboxamide adenosine (stable analog of adenosine)-stimulated cyclic adenosine monophosphate (cAMP) and phosphorylated cAMP- response element binding protein (pCREB) induction, inhibits interleukin (IL)-2 production.M1069 suppresses vascular endothelial growth factor (VEGF) production from human macrophages in adenosine-rich settings.M1069 inhibits protumorigenic cytokine secretion, such as CXCL1, CXCL5 and granulocyte-colony stimulating factor, and reduces IL-12 secretion from adenosine-differentiated dendritic cells.M1069 enhances T-cells activation in adenosine-differentiated dendritic cells.
产品资料
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