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编 号:F762878
分子式:C23H22BrN3O5
分子量:500.34
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生物活性:
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal.

体外研究:
Chitin synthase inhibitor 5 (300 μg/mL; 1 h) inhibits chitin synthase with an IC50 value of 0.14 mM.Chitin synthase inhibitor 5 (1-512 μg/mL; 24 h) shows antifungal activities to C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 26.67, 32, 64 and 64 μg/mL, respectively.
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