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编 号:F762876
分子式:C21H16ClN3O2
分子量:377.82
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生物活性:
LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF).

体外研究:
LasR-IN-2 (Compound 8a, 4.68-150 μg/mL, 24 h) inhibits P. aeruginosa growth.LasR-IN-2 (18.5 μM, 24 h) inhibits biofilm formation, pyocyanin production, and rhamnolipids production.LasR-IN-2 (24 h) inhibits human dermal fibroblasts (HDFa) growth with an IC50 value of 102 μM.
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