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编 号：F762872
分子式：C22H30N6O
分子量：394.51
分子式：C22H30N6O
分子量：394.51
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CAS No: 3033553-63-5
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生物活性：
Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and selective human glutaminyl cyclase (hQC) inhibitor with an IC50 of 3.2 nM.
体内研究：
Glutaminyl Cyclase Inhibitor 5 (Compound 71) (10 mM, 5 μL; ICV; once) 抑制急性阿尔茨海默病小鼠模型中 pE-Aβ3-40 形成，抑制率为 25%。Animal Model:ICR mice (male, six weeks old), acute Alzheimer's disease model
Dosage:10 mM, 5 μL
Administration:Intracerebroventricular injection, once
Result:Suppressed the formation of pE-Aβ3-40 by 25.0%.
体外研究：
Glutaminyl Cyclase Inhibitor 5 (Compound 71) 未表现出明显的 hERG 抑制 (10 μM 抑制率为 47.6%)。Glutaminyl Cyclase Inhibitor 5 可能透过血脑屏障 (-log Pe = 5.5)。
Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and selective human glutaminyl cyclase (hQC) inhibitor with an IC50 of 3.2 nM.
体内研究：
Glutaminyl Cyclase Inhibitor 5 (Compound 71) (10 mM, 5 μL; ICV; once) 抑制急性阿尔茨海默病小鼠模型中 pE-Aβ3-40 形成，抑制率为 25%。Animal Model:ICR mice (male, six weeks old), acute Alzheimer's disease model
Dosage:10 mM, 5 μL
Administration:Intracerebroventricular injection, once
Result:Suppressed the formation of pE-Aβ3-40 by 25.0%.
体外研究：
Glutaminyl Cyclase Inhibitor 5 (Compound 71) 未表现出明显的 hERG 抑制 (10 μM 抑制率为 47.6%)。Glutaminyl Cyclase Inhibitor 5 可能透过血脑屏障 (-log Pe = 5.5)。
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