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编 号:F762867
分子式:C24H25N3O5
分子量:435.47
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生物活性:
Chitin synthase inhibitor 7 (compound 9c) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection.

体外研究:
Chitin synthase inhibitor 7 (compound 9c; 300 μg/mL) inhibits chitin synthase (CHS) activity with an inhibition percentage (IP) value of nearly 70% .Chitin synthase inhibitor 7 (1-512 μg/mL) has antifungal activity against four strains with minimum inhibitory concentration (MIC) values of 128, 256, 256, and 256 μg/mL for C. albicans, A. flavus, A. fumigatus, and C. neoformans, respectively.
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