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编 号:F762866
分子式:C23H23N3O5
分子量:421.45
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生物活性:
Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection.

体外研究:
Chitin synthase inhibitor 8 (compound 9d, 300 μg/mL) inhibits chitin synthase (CHS) by 69%.Chitin synthase inhibitor 8 (0.0625-0.25 μM, 24 h) shows antifungal activities.Chitin synthase inhibitor 8 (32 μg/mL, 24 h) shows strong synergistic effect against A. fumigatus when combinated withFluconazole (HY-10219) .
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