产品
编 号：F762865
分子式：C20H21N5OS
分子量：379.48
分子式：C20H21N5OS
分子量：379.48
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CAS No: 3033646-06-6
产品详情
生物活性：
TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity.
体内研究：
TACC3 inhibitor 1 (20 mg/kg; i.p.; daily for 20 days) 在小鼠体内显示出抗肿瘤活性。Animal Model:Six-week-old BALB/c nude mice (U87 xenograft model)
Dosage:20 mg/kg
Administration:I.p.; daily for 20 days
Result:Exhibited a significant tumor growth regression and no observable toxicity during the administration period and had no effects on the body weight.
体外研究：
TACC3 inhibitor 1 (compound 7g) (1, 2, 4 μM; 36 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期。TACC3 inhibitor 1 (1, 2, 4 μM; 36 h) 降低线粒体膜电位并诱导细胞内 ROS 的产生。TACC3 inhibitor 1 (1, 2, 4 μM; 24 h) 抑制 U87 细胞的迁移和侵袭。
TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity.
体内研究：
TACC3 inhibitor 1 (20 mg/kg; i.p.; daily for 20 days) 在小鼠体内显示出抗肿瘤活性。Animal Model:Six-week-old BALB/c nude mice (U87 xenograft model)
Dosage:20 mg/kg
Administration:I.p.; daily for 20 days
Result:Exhibited a significant tumor growth regression and no observable toxicity during the administration period and had no effects on the body weight.
体外研究：
TACC3 inhibitor 1 (compound 7g) (1, 2, 4 μM; 36 h) 诱导细胞凋亡和细胞周期停滞在 G2/M 期。TACC3 inhibitor 1 (1, 2, 4 μM; 36 h) 降低线粒体膜电位并诱导细胞内 ROS 的产生。TACC3 inhibitor 1 (1, 2, 4 μM; 24 h) 抑制 U87 细胞的迁移和侵袭。
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