产品
编 号:F762820
分子式:C36H46N2O13S
分子量:746.82
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CAS No: 3032633-42-1
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生物活性:
Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 pathway inhibitor, with an IC50 value of 0.38 μM for NO. Anti-inflammatory agent 38 can significantly reduce the level of ROS in cells. Anti-inflammatory agent 38 can be used for researching anti-inflammatory.
体外研究:
Anti-inflammatory agent 38 (compound 23d) (0.25, 0.5, 1 and 2 μM; 3 hours) can reduce ROS production in RAW264.7 cells stimulated with LPS (0.5 μg/mL LPS stimulates for 12 hours).Anti-inflammatory agent 38 (0.25, 0.5, 1 and 2 μM; 3 hours) significantly increases the expression of Nrf2 and HO-1 in LPS-stimulated RAW264.7 cells in a dose-dependent manner, and promoting LPS-induced Nrf2 nuclear translocation