产品
编 号：F762799
分子式：C21H15ClF4N2O4
分子量：470.8
分子式：C21H15ClF4N2O4
分子量：470.8
产品类型
规格
价格
是否有货
结构图
CAS No: 3033087-05-4
产品详情
生物活性：
hDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer.
体内研究：
hDHODH-IN-10 (compound 7d, 30 mg/kg, oral administration) inhibits tumor growth in Raji and HCT116 cells xenograft mice model.hDHODH-IN-10 (500 mg/kg, oral administration) exhibits a favorable safety profile.Animal Model:Raji and HCT116 cells xenograft mice model
Dosage:30 mg/kg
Administration:Oral administration
Result:Showed a tumor growth inhibitory (TGI) rate of 58.3% (Raji model) and 42.1% (HCT116 model).
Animal Model:BALB/c mice (acute toxicity assay)
Dosage:500 mg/kg
Administration:Oral administration
Result:LD50 is about 500 mg/kg.Induced a weak dysfunction of liver.
体外研究：
hDHODH-IN-10 (compound 7d, 1 nM-100 μM) displays anti-proliferative activities against multiple human cancer cells.hDHODH-IN-10 (0.0625-0.25 μM, 24 h) increases the percentage of S-phase cells in Raji and HCT116 cells.
hDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer.
体内研究：
hDHODH-IN-10 (compound 7d, 30 mg/kg, oral administration) inhibits tumor growth in Raji and HCT116 cells xenograft mice model.hDHODH-IN-10 (500 mg/kg, oral administration) exhibits a favorable safety profile.Animal Model:Raji and HCT116 cells xenograft mice model
Dosage:30 mg/kg
Administration:Oral administration
Result:Showed a tumor growth inhibitory (TGI) rate of 58.3% (Raji model) and 42.1% (HCT116 model).
Animal Model:BALB/c mice (acute toxicity assay)
Dosage:500 mg/kg
Administration:Oral administration
Result:LD50 is about 500 mg/kg.Induced a weak dysfunction of liver.
体外研究：
hDHODH-IN-10 (compound 7d, 1 nM-100 μM) displays anti-proliferative activities against multiple human cancer cells.hDHODH-IN-10 (0.0625-0.25 μM, 24 h) increases the percentage of S-phase cells in Raji and HCT116 cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备