产品
编 号：F762797
分子式：C17H18N2O3
分子量：298.34
分子式：C17H18N2O3
分子量：298.34
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CAS No: 3033106-46-3
产品详情
生物活性：
hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
体外研究：
hMAO-B/MB-COMT-IN-2 (compound 8, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-2 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-2 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-2 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit.hMAO-B/MB-COMT-IN-2 (30-50 μM, 24 h) has good safety profile in SK-N-SH cells.
hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
体外研究：
hMAO-B/MB-COMT-IN-2 (compound 8, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-2 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-2 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-2 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit.hMAO-B/MB-COMT-IN-2 (30-50 μM, 24 h) has good safety profile in SK-N-SH cells.
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