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编 号:F762769
分子式:C27H26ClN5OS
分子量:504.05
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生物活性:
CDK1-IN-5 (10h) is a selective CDK1 inhibitor with IC50s of 42.19, 188.71 and 354.15 nM for CDK1, CDK2 and CDK5, respectively. CDK1-IN-5 inhibits growth of cancer cells by affecting cell cycle. CDK1-IN-5 can be used for the research of cancer.

体外研究:
CDK1-IN-5 (0-10 μM; 24 h) inhibits the growth of various cancer cells.CDK1-IN-5 (0-1 μM) inhibits CDK1, CDK2 and CDK5 with IC50s of 42.19, 188.71 and 354.15 nM, respectively.CDK1-IN-5 (0-10 μM) inhibits AXL, PTK2B, FGFR, JAK1, IGF1R and BRAF kinases with IC50s of 5649, 8945, 2538, 2417, 8546 and 8138 nM, respectively.CDK1-IN-5 (0.73 μM; 24 h) decreases CDK1 protein level in virto and affects cell cycle.
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