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编 号:F762767
分子式:C40H64N16
分子量:769.04
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生物活性:
Antimicrobial agent-6 (Compound 11) is an antimicrobial agent with a MIC range of 4-8 μg/mL against gram-positive and gram-negative bacteria. Antimicrobial agent-6 also shows anti-inflammatory activity.

体外研究:
Antimicrobial agent-6 (Compound 11) (0-256 μg/mL; 18-24 h) shows antibacterial activity with geometric mean (GM) values of the MICs of 5 μg/mL.Antimicrobial agent-6 shows minimum hemolytic concentration (MHC) of >256 μg/mL, the therapeutic index is 102.4.Antimicrobial agent-6 (5 or 20 μg/mL; 18 h) effectively inhibits the release and expression of NO and TNF-α from LPS-stimulated RAW 264.7 cells.Antimicrobial agent-6 is resistant to various physiological salts, human serum, and proteases.
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