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编 号:F762745
分子式:C39H38BrClNO2P
分子量:699.06
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生物活性:
Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide.

体内研究:
Antifungal agent 47 (compound 3b) (200 μg/mL) 显示出对番茄果实中 B. cinerea 的杀真菌活性。Animal Model:Tomato fruits in both protective and curative modes
Dosage:200 μg/mL
Administration:
Result:Inhibited the growth of B. cinerea in tomato fruits. It received 59.01% control efficacy in protective mode and 53.56% control efficacy in curative mode.

体外研究:
Antifungal agent 47 (compound 3b) 对五种植物病原真菌(P. capsici、R. solani、B. cinerea、P. aphanidermatum 和 S. sclerotiorum)具有杀菌活性,EC50 值分别为 12.70、21.74、22.42、11.00 和 4.78 μM。Antifungal agent 47 (35 μM, 3 h) 抑制 P. capsici 菌丝体的 ATP 产生,抑制率为 61.70±3.64%。Antifungal agent 47 对线粒体的作用大大改善,如通过破坏病原体的线粒体功能,引起线粒体肿胀,减弱其对细胞壁形态的影响等。
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