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编 号：F762742
分子式：C32H48N16
分子量：656.83
分子式：C32H48N16
分子量：656.83
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CAS No: 2978694-04-9
产品详情
生物活性：
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation.
体外研究：
Antimicrobial agent-5 (compound 9) (0.5-32 μg/mL, 16 h; 1-128 μg/mL; 24 h) shows potent biofilm inhibitory (IC50=2 μg/mL) and eradicating activities (IC50=16 μg/mL) against multidrug-resistant Pseudomonas aeruginosa (MDRPA).Antimicrobial agent-5 (5 μgmL, 20 μg/mL; 18 h) inhibits both the release and expression of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) from LPS-stimulated (1 μg/mL) RAW 264.7 cells.Antimicrobial agent-5 exhibits proteolytic resistance and salt/serum stability.Antimicrobial agent-5 (0.5-256 μg/mL; 2 h) exhibits negligible side effects against sheep red blood cells (sRBCs) with hemolytic activity (the minimum hemolytic concentration, MHC) of >256 μg/mL.
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation.
体外研究：
Antimicrobial agent-5 (compound 9) (0.5-32 μg/mL, 16 h; 1-128 μg/mL; 24 h) shows potent biofilm inhibitory (IC50=2 μg/mL) and eradicating activities (IC50=16 μg/mL) against multidrug-resistant Pseudomonas aeruginosa (MDRPA).Antimicrobial agent-5 (5 μgmL, 20 μg/mL; 18 h) inhibits both the release and expression of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) from LPS-stimulated (1 μg/mL) RAW 264.7 cells.Antimicrobial agent-5 exhibits proteolytic resistance and salt/serum stability.Antimicrobial agent-5 (0.5-256 μg/mL; 2 h) exhibits negligible side effects against sheep red blood cells (sRBCs) with hemolytic activity (the minimum hemolytic concentration, MHC) of >256 μg/mL.
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