产品
编 号：F762714
分子式：C30H24ClN3O5
分子量：541.98
分子式：C30H24ClN3O5
分子量：541.98
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规格
价格
是否有货
结构图
CAS No: 2983723-56-2
产品详情
生物活性：
hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE， MAO-B-IN-1 and BACE-1 inhibitor, with IC50 values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease.
体外研究：
hAChE-IN-3 (compounds 5c) 对 SH-SY5Y 细胞系的 IC50 值为 36.28 μM(24 h)，对 HepG2 细胞系的IC50 值为 154.10 μM(48 h)。hAChE-IN-3 对 β - 淀粉样斑块聚集的 IC50 值为2.58 μM，抑制率为59% (10 μM)。
hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE, BuChE， MAO-B-IN-1 and BACE-1 inhibitor, with IC50 values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease.
体外研究：
hAChE-IN-3 (compounds 5c) 对 SH-SY5Y 细胞系的 IC50 值为 36.28 μM(24 h)，对 HepG2 细胞系的IC50 值为 154.10 μM(48 h)。hAChE-IN-3 对 β - 淀粉样斑块聚集的 IC50 值为2.58 μM，抑制率为59% (10 μM)。
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