产品
编 号：F762677
分子式：C30H42N2O6
分子量：526.66
分子式：C30H42N2O6
分子量：526.66
产品类型
规格
价格
是否有货
结构图
CAS No: 2780409-77-8
产品详情
生物活性：
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae.
体外研究：
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) (0.0625 -128 μg/mL, 8 h) shows antibacterial activity with MICs of 0.0625, 0.5, 8, 0.125, 0.0625, and 0.5 μg/mL against MSSA, MRSA, E.faecium, M.pneumonia (ATCC15331), M.pneumonia (ATCC29342), and M.pneumonia (resistant strain, clinically isolated strain), respectively.22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (0-10 μg/mL, 72 h) shows low cytotoxicity in human cancer cells.22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin exhibits good ADMET properties with high LogS, attractive ALogP, low PPB, non-Ames toxic, and non-carcinogenic.
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) is an antibacterial pleuromutilin derivative against Gram-positive pathogens (GPPs) and Mycoplasma pneumoniae.
体外研究：
22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (compound 6n) (0.0625 -128 μg/mL, 8 h) shows antibacterial activity with MICs of 0.0625, 0.5, 8, 0.125, 0.0625, and 0.5 μg/mL against MSSA, MRSA, E.faecium, M.pneumonia (ATCC15331), M.pneumonia (ATCC29342), and M.pneumonia (resistant strain, clinically isolated strain), respectively.22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin (0-10 μg/mL, 72 h) shows low cytotoxicity in human cancer cells.22-((4-Methoxyphenyl)urea-1-yl)-22-deoxypleuromutilin exhibits good ADMET properties with high LogS, attractive ALogP, low PPB, non-Ames toxic, and non-carcinogenic.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备