产品
编 号：F762669
分子式：C22H20ClN3O3
分子量：409.87
分子式：C22H20ClN3O3
分子量：409.87
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CAS No: 2763387-69-3
产品详情
生物活性：
Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants.
体外研究：
Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 μg/mL in Candidaalbicans (C. albicans) ATCC 76615 and Aspergillus fumigatus (A. fumigatus) GIMCC 3.19; MIC=8 μg/mL in Aspergillus flavus (A. flavus) ATCC 16870 and Crytococcusneoformans (C. neoformans) ATCC 32719).Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 μg/mL in FluconazoleresistantC.albicans ATCC 76615R, Fluconazole-resistant A.fumigatus GIMCC 3.19R, and Fluconazole-resistant C. neoformans ATCC 32719R, Micafunginresistant C.albicans ATCC 76615R’; MIC=16 μg/mL in Fluconazole-resistant A.flavus ATCC 16870R).
Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants.
体外研究：
Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 μg/mL in Candidaalbicans (C. albicans) ATCC 76615 and Aspergillus fumigatus (A. fumigatus) GIMCC 3.19; MIC=8 μg/mL in Aspergillus flavus (A. flavus) ATCC 16870 and Crytococcusneoformans (C. neoformans) ATCC 32719).Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 μg/mL in FluconazoleresistantC.albicans ATCC 76615R, Fluconazole-resistant A.fumigatus GIMCC 3.19R, and Fluconazole-resistant C. neoformans ATCC 32719R, Micafunginresistant C.albicans ATCC 76615R’; MIC=16 μg/mL in Fluconazole-resistant A.flavus ATCC 16870R).
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