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编 号:F762641
分子式:C21H17N5O2S
分子量:403.46
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生物活性:
MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection.

体外研究:
MKA031 (compound 6y) (1-100 μl;3 h) 阻止 MNNG 诱导的细胞死亡。MKA031 (compound 6y) (100 μl;3 h) 通过阻断 MIF 向 AIF 的募集来保护基因组 DNA。
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