产品
编 号：F762616
分子式：C27H36F3N7O5S
分子量：627.68
分子式：C27H36F3N7O5S
分子量：627.68
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 3007772-60-0
产品详情
生物活性：
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 μM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells.
体外研究：
ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells.ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells.
ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, with an IC50 of 0.21 μM for ABHD17B. ABD957 can block N-Ras signaling and the growth of NRAS-mutant AML cells.
体外研究：
ABD957 (500 nM; pretreated for 1 h) attenuates N-Ras depalmitoylation in AML cells.ABD957 (0.11 nM-10 μM; 72 h) blocks the signaling and proliferation of NRAS-mutant leukemia cells.
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