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编 号：F762607
分子式：C30H37N3O
分子量：455.63
分子式：C30H37N3O
分子量：455.63
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CAS No: 2999636-75-6
产品详情
生物活性：
sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.
体内研究：
sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 对 Cerulein (HY-A0190) 诱导的小鼠急性胰腺炎具有保护作用。sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 显示在 CD-1 小鼠中 T1/2 为 7.6 小时，Cmax 为 4.17 ng/mL。Animal Model:The murine model of AP induced by repeated Cerulein (HY-A0190) injections
Dosage:10mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Displayed aprotective effect evidenced bythereduction ofedema, cell infiltration, and neutrophil numbers.
Animal Model:Male CD-1 mice (Pharmacokinetic assay)
Dosage:10mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Pharmacokinetic parameters for sEH inhibitor-16 (Compound 28) in CD-1 miceRouteDose (mg/kg)T1/2 (h) Tmax (h) Cmax (ng/mL)AUC0-? (h?ng/mL)
i.p.107.624.1729.9
sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research.
体内研究：
sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 对 Cerulein (HY-A0190) 诱导的小鼠急性胰腺炎具有保护作用。sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 显示在 CD-1 小鼠中 T1/2 为 7.6 小时，Cmax 为 4.17 ng/mL。Animal Model:The murine model of AP induced by repeated Cerulein (HY-A0190) injections
Dosage:10mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Displayed aprotective effect evidenced bythereduction ofedema, cell infiltration, and neutrophil numbers.
Animal Model:Male CD-1 mice (Pharmacokinetic assay)
Dosage:10mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Pharmacokinetic parameters for sEH inhibitor-16 (Compound 28) in CD-1 miceRouteDose (mg/kg)T1/2 (h) Tmax (h) Cmax (ng/mL)AUC0-? (h?ng/mL)
i.p.107.624.1729.9
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