产品
编 号：F762602
分子式：C30H33N7O3
分子量：539.63
分子式：C30H33N7O3
分子量：539.63
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规格
价格
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结构图
CAS No: 3003026-16-9
产品详情
生物活性：
HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch.
体内研究：
HPK1-IN-31(compound 5i) (p.o., 30 or 100 mpk twice daily, 14 days) inhibits tumour growth in the CT26 tumour-bearing female BALB/c mouse model and the MC38 tumour-bearing female C57BL/6 mouse model, and is followed by a significant effect when combined with anti-PD-1 monotherapy.The pharmacokinetic parameters of HPK1-IN-31(compound 5i)in Mice and Beagles mice beagles5i1 mg/kg (i.v.)20 mg/kg (i.g.)1 mg/kg (i.v.)5 mg/kg (i.g.)T1/2 (h)1.33.78.16.2Tmax (h)-0.8-1.0Cmax (ng/mL)111820481811.2539.3AUC(0-inf)(ng*h/mL)86085283132.24094.9MRT (h)1.03.97.38.1CL (mL/min/kg)19.7-5.9-F (%)-49-27
HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch.
体内研究：
HPK1-IN-31(compound 5i) (p.o., 30 or 100 mpk twice daily, 14 days) inhibits tumour growth in the CT26 tumour-bearing female BALB/c mouse model and the MC38 tumour-bearing female C57BL/6 mouse model, and is followed by a significant effect when combined with anti-PD-1 monotherapy.The pharmacokinetic parameters of HPK1-IN-31(compound 5i)in Mice and Beagles mice beagles5i1 mg/kg (i.v.)20 mg/kg (i.g.)1 mg/kg (i.v.)5 mg/kg (i.g.)T1/2 (h)1.33.78.16.2Tmax (h)-0.8-1.0Cmax (ng/mL)111820481811.2539.3AUC(0-inf)(ng*h/mL)86085283132.24094.9MRT (h)1.03.97.38.1CL (mL/min/kg)19.7-5.9-F (%)-49-27
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