产品
编 号：F762598
分子式：C22H19ClF3N5O2
分子量：477.87
分子式：C22H19ClF3N5O2
分子量：477.87
产品类型
规格
价格
是否有货
结构图
CAS No: 2999742-92-4
产品详情
生物活性：
CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 can be used for the research of cancer.
体内研究：
CBP/p300-IN-20 (compound 28) (0.54 mg/kg; i.v.) exhibits Cmax (210 ng/mL), AUC0→∞ (102 h?ng/mL), CL (95 mL/min/kg), and T1/2 (0.3 h) in rats.
体外研究：
CBP/p300-IN-20 (compound 28) decreases Myc protein in cell-based cMyc HTRF assay, with a pEC50 of 8.5.CBP/p300-IN-20 (1 μM) shows 97% inhibition for p300 and 80% inhibition for CPB.CBP/p300-IN-20 (0.3-1000 nM; 2 h) decreases H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3 in COLO 320HSR cells.
CBP/p300-IN-20 is a potent and selective p300/CBP inhibitor, with a pIC50 of 10.1 for p300. CBP/p300-IN-20 can be used for the research of cancer.
体内研究：
CBP/p300-IN-20 (compound 28) (0.54 mg/kg; i.v.) exhibits Cmax (210 ng/mL), AUC0→∞ (102 h?ng/mL), CL (95 mL/min/kg), and T1/2 (0.3 h) in rats.
体外研究：
CBP/p300-IN-20 (compound 28) decreases Myc protein in cell-based cMyc HTRF assay, with a pEC50 of 8.5.CBP/p300-IN-20 (1 μM) shows 97% inhibition for p300 and 80% inhibition for CPB.CBP/p300-IN-20 (0.3-1000 nM; 2 h) decreases H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3 in COLO 320HSR cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备