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编 号：F762591
分子式：C26H25N3O4S
分子量：475.56
分子式：C26H25N3O4S
分子量：475.56
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CAS No: 3009090-13-2
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生物活性：
Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma.
体内研究：
Anticancer agent 106 (9-9.5 mg/kg; i.p.; every 3rd d for 22 d) 抑制肺转移性黑色素瘤小鼠模型中的转移性结节。Animal Model:B16-F10 melanoma-bearing C57BL/6 mice (pulmonary metastatic melanoma model).
Dosage:9-9.5 mg/kg
Administration:Intraperitoneal administration; every 3rd d for 22 d.
Result:Inhibited the lung metastases.
体外研究：
Anticancer agent 106 (化合物 10ic; 0.28-55 μM; 24 h) 以剂量依赖性方式降低 B16-F10 黑色素瘤细胞的活力，IC50 值为 4.8 μM。Anticancer agent 106 (5-20 μM; 48 h) 诱导 B16-F10 黑色素瘤细胞凋亡。
Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma.
体内研究：
Anticancer agent 106 (9-9.5 mg/kg; i.p.; every 3rd d for 22 d) 抑制肺转移性黑色素瘤小鼠模型中的转移性结节。Animal Model:B16-F10 melanoma-bearing C57BL/6 mice (pulmonary metastatic melanoma model).
Dosage:9-9.5 mg/kg
Administration:Intraperitoneal administration; every 3rd d for 22 d.
Result:Inhibited the lung metastases.
体外研究：
Anticancer agent 106 (化合物 10ic; 0.28-55 μM; 24 h) 以剂量依赖性方式降低 B16-F10 黑色素瘤细胞的活力，IC50 值为 4.8 μM。Anticancer agent 106 (5-20 μM; 48 h) 诱导 B16-F10 黑色素瘤细胞凋亡。
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