产品
编 号：F762581
分子式：C21H22N6O2
分子量：390.44
分子式：C21H22N6O2
分子量：390.44
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CAS No: 3018859-95-2
产品详情
生物活性：
Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML).
体外研究：
Syk-IN-6 (WC36) specifically and potently suppresses oncogenic activities of Syk in AML cell lines and patient-derived AML cells.Syk-IN-6 (5 μM; 16 h) inhibits FcγRI-specific antibody (IgG2)-stimulated phosphorylation of Syk, STAT3/STAT5 and ERK1/2 in naive MV4-11 cells rather not entospletinib-resistant/Syk-deficient MV4-11 cells.Syk-IN-6 (0.01 μM-100 μM; 16 h) inhibits the proliferation of MV4-11 cells, HL-60 and patient-derived AML cells by SykcSH2 dose-dependently.
Syk-IN-6 is an inhibitor of the lipid-SH2 domain interaction, control the cellular activity of kinases containing SH2 domain. Syk-IN-6 blocks Syk kinase activity, which associated hematopoietic malignancies, including acute myeloid leukemia (AML).
体外研究：
Syk-IN-6 (WC36) specifically and potently suppresses oncogenic activities of Syk in AML cell lines and patient-derived AML cells.Syk-IN-6 (5 μM; 16 h) inhibits FcγRI-specific antibody (IgG2)-stimulated phosphorylation of Syk, STAT3/STAT5 and ERK1/2 in naive MV4-11 cells rather not entospletinib-resistant/Syk-deficient MV4-11 cells.Syk-IN-6 (0.01 μM-100 μM; 16 h) inhibits the proliferation of MV4-11 cells, HL-60 and patient-derived AML cells by SykcSH2 dose-dependently.
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