产品
编 号：F762550
分子式：C24H20N4O
分子量：380.44
分子式：C24H20N4O
分子量：380.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2988566-71-6
产品详情
生物活性：
Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 has a highly selective inhibition of PDE2A (IC50=0.57 μM) and over 250-fold selectivity against other recombinant PDE family members. Hcyb1 produces neuroprotective and antidepressant‐like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling.
体内研究：
Hcyb1 (0.5, 1, and 2 mg/kg, i.g.) decreases the immobility time in both forced swimming and tail suspension tests, without altering locomotor activity.Animal Model:Male imprinting control region (ICR) mice, weighing between 20 and 25 g
Dosage:0.5, 1, and 2 mg/kg
Administration:Gavage (i.g.)
Result:Exhibited dose-dependent reduction in immobility time at doses of 0.5, 1, 2 mg/kg (i.g.).
体外研究：
Hcyb1 (1~100 nM; 10 minutes) increases cGMP levels by 1.7~2.3 folds.Hcyb1 (1 nM; 24 hours) increases both cGMP and cAMP levels.Hcyb1 (24 hours) treatment also increases the levels of phosphorylation of CREB and BDNF in HT-22 cells.Hcyb1 promotes HT-22 cell viability and increase the cGMP and cAMP accumulation in HT-22 cells.Hcyb1 exhibits the concentration- and time-dependent effects on cell viability in HT-22 cells.
Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 has a highly selective inhibition of PDE2A (IC50=0.57 μM) and over 250-fold selectivity against other recombinant PDE family members. Hcyb1 produces neuroprotective and antidepressant‐like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling.
体内研究：
Hcyb1 (0.5, 1, and 2 mg/kg, i.g.) decreases the immobility time in both forced swimming and tail suspension tests, without altering locomotor activity.Animal Model:Male imprinting control region (ICR) mice, weighing between 20 and 25 g
Dosage:0.5, 1, and 2 mg/kg
Administration:Gavage (i.g.)
Result:Exhibited dose-dependent reduction in immobility time at doses of 0.5, 1, 2 mg/kg (i.g.).
体外研究：
Hcyb1 (1~100 nM; 10 minutes) increases cGMP levels by 1.7~2.3 folds.Hcyb1 (1 nM; 24 hours) increases both cGMP and cAMP levels.Hcyb1 (24 hours) treatment also increases the levels of phosphorylation of CREB and BDNF in HT-22 cells.Hcyb1 promotes HT-22 cell viability and increase the cGMP and cAMP accumulation in HT-22 cells.Hcyb1 exhibits the concentration- and time-dependent effects on cell viability in HT-22 cells.
产品资料
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