产品
编 号：F762528
分子式：C22H21N3O4
分子量：391.42
分子式：C22H21N3O4
分子量：391.42
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CAS No: 2987726-27-0
产品详情
生物活性：
STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase.
体外研究：
STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 μM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.STAT3-IN-9 (0, 0.2, 1.0, 5.0 μM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway.STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner.
STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase.
体外研究：
STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 μM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.STAT3-IN-9 (0, 0.2, 1.0, 5.0 μM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway.STAT3-IN-9 (0, 0.2, 1 μM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner.
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