产品
编 号:F762502
分子式:C19H15FN2O
分子量:306.33
产品类型
结构图
CAS No: 2990506-75-5
联系客服
产品详情
生物活性:
ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究:
ML353 是一种充分可溶性化合物,在 PBS 中的溶解度为 16.9 μM 或 6.0 μg/mL (PH=7.4)。ML353 在 PBS 缓冲液中具有优异的稳定性。