产品
编 号：F762500
分子式：C25H21FN4O3
分子量：444.46
分子式：C25H21FN4O3
分子量：444.46
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2991637-98-8
产品详情
生物活性：
DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
DB008 (0-1 μM; 0-120 分钟; HEK 293T 细胞) 共价修饰 PARP16 的 Cys169，并在不可逆结合模式下表现出出色的全蛋白质组选择性。DB008 (100 nM; 16小时; HAP1 WT 和 HAP1 PARP16 KO 细胞) 挽救营养饥饿诱导的可溶性 PARP16 损失。
DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
DB008 (0-1 μM; 0-120 分钟; HEK 293T 细胞) 共价修饰 PARP16 的 Cys169，并在不可逆结合模式下表现出出色的全蛋白质组选择性。DB008 (100 nM; 16小时; HAP1 WT 和 HAP1 PARP16 KO 细胞) 挽救营养饥饿诱导的可溶性 PARP16 损失。
产品资料
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