产品
编 号：F762484
分子式：C24H19ClN4OS
分子量：446.95
分子式：C24H19ClN4OS
分子量：446.95
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2489196-70-3
产品详情
生物活性：
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.
体内研究：
mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis.Animal Model:Fertile chicken eggs (7-9 days old)
Dosage:25 and 50 μM
Administration:6 days
Result:Significant xenograft tumor remission was observed in eggs compared with the DMSO-treated eggs.
体外研究：
mTOR inhibitor-8 (Compound 5e; 0.1-10?μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner.mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10?μM; 3-24?hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced.mTOR inhibitor-8 (10?μM; 3-24?hours)reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.
体内研究：
mTOR inhibitor-8 (25 and 50 μM; 6 days) effectively inhibits tumor growth in vivo without adverse effect on normal chick chorioallantoic membrane angiogenesis.Animal Model:Fertile chicken eggs (7-9 days old)
Dosage:25 and 50 μM
Administration:6 days
Result:Significant xenograft tumor remission was observed in eggs compared with the DMSO-treated eggs.
体外研究：
mTOR inhibitor-8 (Compound 5e; 0.1-10?μM; 24 and 48 hours) suppresses the growth of A549 cells in a dose-dependent manner.mTOR inhibitor-8 induces autophagy in an mTOR-dependent manner. mTOR inhibitor-8 (10?μM; 3-24?hours) induces autophagy in a time-dependent manner. The levels of LC3B-II are enhanced.mTOR inhibitor-8 (10?μM; 3-24?hours)reduces the phosphorylation of RPS6KB1 (ribosomal protein S6 kinase) and EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1), two essential substrates of mTOR
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