产品
编 号：F762483
分子式：C24H22ClFN2O3
分子量：440.89
分子式：C24H22ClFN2O3
分子量：440.89
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2489226-14-2
产品详情
生物活性：
AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.
体内研究：
AZD4747 (1.1-2.3 μM/kg (i.v.); 2.3-6.8 μM/kg (p.o.); 单次) 显示出中度至高的清除率，小鼠和大鼠的肝血流量分别为 52% 和 75%。Animal Model:Male CD1 mice, male Wistar Han rats.
Dosage:Mouse: 2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.);Rat: 1.1-2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.).
Administration:i.v. and p.o.
Result:1.19Pharmacokinetic Parameters of AZD4747 in Cross Species.MouseRat
IVa POaIVa POa
Eh (%)5275
Vss (L/kg)2.91.7
T1/2 (h)0.630.56
F%5818
Note:a: 5% DMSO, 95% SBE-B-CD (30% w/v) in water.
AZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.
体内研究：
AZD4747 (1.1-2.3 μM/kg (i.v.); 2.3-6.8 μM/kg (p.o.); 单次) 显示出中度至高的清除率，小鼠和大鼠的肝血流量分别为 52% 和 75%。Animal Model:Male CD1 mice, male Wistar Han rats.
Dosage:Mouse: 2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.);Rat: 1.1-2.3 μM/kg (i.v.); 6.8 μM/kg (p.o.).
Administration:i.v. and p.o.
Result:1.19Pharmacokinetic Parameters of AZD4747 in Cross Species.MouseRat
IVa POaIVa POa
Eh (%)5275
Vss (L/kg)2.91.7
T1/2 (h)0.630.56
F%5818
Note:a: 5% DMSO, 95% SBE-B-CD (30% w/v) in water.
产品资料
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