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编 号：F762482
分子式：C18H20Cl2N4O2S
分子量：427.35
分子式：C18H20Cl2N4O2S
分子量：427.35
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CAS No: 1979935-34-6
产品详情
生物活性：
ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.
体内研究：
ORC-13661 (0.2-5 mg/kg; 口服; 每日一次, 持续 10 天) hydrochloride 以剂量依赖性方式保护大鼠的听力免受阿米卡星的影响。Animal Model:Male Fischer 344 rat
Dosage:0.2, 1, and 5 mg/kg
Administration:Oral administration; daily, for 10 days
Result:Protected hearing in mammals from different AG antibiotics.
体外研究：
ORC-13661 (0.10-8.3 μM；野生型 *AB 斑马鱼毛细胞) hydrochloride 保护斑马鱼毛细胞免受多种氨基糖苷类 (AG) 的影响。ORC-13661 (0.10-20 μM) hydrochloride 保护斑马鱼侧线毛细胞和哺乳动物毛细胞免受 Cisplatin (HY-17394) 影响。ORC-13661 (0.3 and 3 μM) hydrochloride 是听觉毛细胞 MET 通道的可逆阻断剂。ORC-13661 hydrochloride 阻断 OHC MET 电流。ORC-13661 hydrochloride MET 通道块具有电压依赖性和渗透性。
ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker.
体内研究：
ORC-13661 (0.2-5 mg/kg; 口服; 每日一次, 持续 10 天) hydrochloride 以剂量依赖性方式保护大鼠的听力免受阿米卡星的影响。Animal Model:Male Fischer 344 rat
Dosage:0.2, 1, and 5 mg/kg
Administration:Oral administration; daily, for 10 days
Result:Protected hearing in mammals from different AG antibiotics.
体外研究：
ORC-13661 (0.10-8.3 μM；野生型 *AB 斑马鱼毛细胞) hydrochloride 保护斑马鱼毛细胞免受多种氨基糖苷类 (AG) 的影响。ORC-13661 (0.10-20 μM) hydrochloride 保护斑马鱼侧线毛细胞和哺乳动物毛细胞免受 Cisplatin (HY-17394) 影响。ORC-13661 (0.3 and 3 μM) hydrochloride 是听觉毛细胞 MET 通道的可逆阻断剂。ORC-13661 hydrochloride 阻断 OHC MET 电流。ORC-13661 hydrochloride MET 通道块具有电压依赖性和渗透性。
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