产品
编 号：F084754
分子式：C21H38N4O9
分子量：490.55
分子式：C21H38N4O9
分子量：490.55
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CAS No: 1233643-88-3
产品详情
生物活性：
Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.
体内研究：
Laninamivir octanoate (CS-8958；95μg/kg；鼻内的管理；3 次) 在感染前 4 h、感染后 4 h 和 17 h 处理，在小鼠感染模型中均有明显的延长寿命效果。Animal Model:Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34
Dosage:0.2 μmol/kg (95 μg/kg)
Administration:Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection
Result:Showed life-prolonging effect in infected model.
体外研究：
Laninamivir octanoate (CS-8958) 对 H1N1 病毒株、H3N2 病毒株和 H2N2 (A/Singapore/1/57) 病毒株具有抑菌活性，IC50 分别为 631-1170 nM、39.2-221 nM 和 128 nM 。
Laninamivir octanoate hydrate (CS-8958 hydrate), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate hydrate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.
体内研究：
Laninamivir octanoate (CS-8958；95μg/kg；鼻内的管理；3 次) 在感染前 4 h、感染后 4 h 和 17 h 处理，在小鼠感染模型中均有明显的延长寿命效果。Animal Model:Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34
Dosage:0.2 μmol/kg (95 μg/kg)
Administration:Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection
Result:Showed life-prolonging effect in infected model.
体外研究：
Laninamivir octanoate (CS-8958) 对 H1N1 病毒株、H3N2 病毒株和 H2N2 (A/Singapore/1/57) 病毒株具有抑菌活性，IC50 分别为 631-1170 nM、39.2-221 nM 和 128 nM 。
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