产品
编 号:F762425
分子式:C17H18N6
分子量:306.37
产品类型
结构图
CAS No: 2227110-54-3
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产品详情
生物活性:
3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer.
体外研究:
3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC50 values of 108, 94 and 108 nM, respectively.3-IN-PP1 (5 μM, 0-114 h) displays potent anti-proliferative activity against PANC-1 cells.3-IN-PP1 (20 μM, 1 h) potently blocks PKD-dependent cortactin phosphorylation in PANC-1 cells.3-IN-PP1 has inhibition of different tumor cell growth with IC50 values range from 1.6 to 39.2μM.