产品
编 号：F762400
分子式：C18H15FO4
分子量：314.31
分子式：C18H15FO4
分子量：314.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2407652-42-8
产品详情
生物活性：
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases.
体内研究：
IRG1-IN-1 (compound 6) (i.p.; 0.2 mg/kg; 27 days) shows antitumor effect in C57BL/6 mice.Animal Model:C57BL/6 mice
Dosage:0.2 mg/kg
Administration:IP; 27 days
Result:Increased survival of C57BL/6 mice bearing mouse CT26 colorectal tumors.Decreased intratumoral frequency of M-MDSCs in tumors.
体外研究：
IRG1-IN-1(compound 6) (0.5 mM; 2 mM) reduces production of itaconic acid and the secretion of TNFα from LPS-stimulated human monocyte derived macrophages (hMDMs) .IRG1-IN-1 (0.5 mM; 1 mM) inhibits the proliferation of C-IRG1-9 rat glioma cells.IRG1-IN-1(10 nM) increases proliferation of TCR-activated hCD8+ T cells.IRG1-IN-1(10μM) shows depletion of trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8+ T cells.
IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases.
体内研究：
IRG1-IN-1 (compound 6) (i.p.; 0.2 mg/kg; 27 days) shows antitumor effect in C57BL/6 mice.Animal Model:C57BL/6 mice
Dosage:0.2 mg/kg
Administration:IP; 27 days
Result:Increased survival of C57BL/6 mice bearing mouse CT26 colorectal tumors.Decreased intratumoral frequency of M-MDSCs in tumors.
体外研究：
IRG1-IN-1(compound 6) (0.5 mM; 2 mM) reduces production of itaconic acid and the secretion of TNFα from LPS-stimulated human monocyte derived macrophages (hMDMs) .IRG1-IN-1 (0.5 mM; 1 mM) inhibits the proliferation of C-IRG1-9 rat glioma cells.IRG1-IN-1(10 nM) increases proliferation of TCR-activated hCD8+ T cells.IRG1-IN-1(10μM) shows depletion of trimethylation of histone 3 at lysine 4 (H3K4me3) in CR-activated hCD8+ T cells.
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