产品
编 号：F762361
分子式：C24H24N4O6
分子量：464.47
分子式：C24H24N4O6
分子量：464.47
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CAS No: 1349084-71-4
产品详情
生物活性：
(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
体内研究：
(1R,3S)-THCCA-Asn (4j) (p.o., 0.001-1 nM/kg) can act against thrombosis of rats in a dose-dependent manner with no toxic side effects.Animal Model:Male SD (Sprague Dawley) rats weighing 250-300 g
Dosage:0.001, 0.01, 1 nM/kg
Administration:p.o.
Result:Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.
体外研究：
(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%.(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro.
(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
体内研究：
(1R,3S)-THCCA-Asn (4j) (p.o., 0.001-1 nM/kg) can act against thrombosis of rats in a dose-dependent manner with no toxic side effects.Animal Model:Male SD (Sprague Dawley) rats weighing 250-300 g
Dosage:0.001, 0.01, 1 nM/kg
Administration:p.o.
Result:Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.
体外研究：
(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%.(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro.
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