产品
编 号：F762351
分子式：C36H45ClN4O
分子量：585.22
分子式：C36H45ClN4O
分子量：585.22
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 104264-80-4
产品详情
生物活性：
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.
体内研究：
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice.Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days.Animal Model:Plasmodium berghei in infected mice
Dosage:50 or 100 mol/kg
Administration:Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:Inhibited the growth of the rodent malaria parasite Plasmodium berghei.Prolonged the survival of highly parasitaemic mice.
体外研究：
Manzamine A (5-50 μM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA.Manzamine A (10 μM) hydrochloride inhibits yeast S. cerevisiae growth by 30%.Manzamine A hydrochloride displays a few enlarged vacuoles in yeast.Manzamine A (2.5-10 μM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells.Manzamine A (1 μM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells.Manzamine A hydrochloride shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone).
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.
体内研究：
Manzamine A (50 and 100 mol/kg, p.o. or i.p.) hydrochloride inhibits the growth of the rodent malaria parasite Plasmodium berghei in infected mice.Manzamine A (8 mg/kg, i.p., daily for 8 consecutive days) hydrochloride prolongs the survival of SW mice to 20 days.Animal Model:Plasmodium berghei in infected mice
Dosage:50 or 100 mol/kg
Administration:Intraperitoneal injection (i.p.) or oral administration (p.o.)
Result:Inhibited the growth of the rodent malaria parasite Plasmodium berghei.Prolonged the survival of highly parasitaemic mice.
体外研究：
Manzamine A (5-50 μM, 18 h) hydrochloride decreases tau phosphorylation, measured with ELISA.Manzamine A (10 μM) hydrochloride inhibits yeast S. cerevisiae growth by 30%.Manzamine A hydrochloride displays a few enlarged vacuoles in yeast.Manzamine A (2.5-10 μM, 24 h) hydrochloride increases acidity in pancreatic cancer cells and non-malignant Vero cells.Manzamine A (1 μM, 24 h) hydrochloride inhibits HSV-1 infection in SIRC cells.Manzamine A hydrochloride shows antimalarial activity with an IC50 of 8.0 nM (D6 clone) and 11 nM (W2 clone).
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