产品
编 号：F762310
分子式：C76H100N18O19S2
分子量：1633.85
分子式：C76H100N18O19S2
分子量：1633.85
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CAS No: 405137-01-1
产品详情
生物活性：
Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system.
体内研究：
Urotensin II is a somatostatin-like cyclic peptide which functions as an arterial vasocontrictor, vasodilator, and bronchoconstriction mediator. Urotensin II (0.1 nmol, 0.3 nmol, and 3 nmol; intracerebroventricular administration) induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner.Animal Model:Male C57BL/6N mice (8 weeks old)
Dosage:0.1 nmol, 0.3 nmol, and 3 nmol
Administration:Intracerebroventricular (i.c.v.) administration
Result:Decreased the amount of head dipping without significant alteration of the motor activity.
体外研究：
This sequence of the C-terminus cyclic region of Urotensin II (U-II) is completely conserved in most species, including in the fish, frog, human, porcine, rat, and mouse, and it is thought to be essential for the agonistic activity of U-II. Urotensin II plays a physiological role in the central nervous system. Intracerebroventricular administration of Urotensin II induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner, as do corticotropin releasing factor (CRF). The effective doses of Urotensin II are 10-100-fold higher than these of CRF in these tests.
Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system.
体内研究：
Urotensin II is a somatostatin-like cyclic peptide which functions as an arterial vasocontrictor, vasodilator, and bronchoconstriction mediator. Urotensin II (0.1 nmol, 0.3 nmol, and 3 nmol; intracerebroventricular administration) induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner.Animal Model:Male C57BL/6N mice (8 weeks old)
Dosage:0.1 nmol, 0.3 nmol, and 3 nmol
Administration:Intracerebroventricular (i.c.v.) administration
Result:Decreased the amount of head dipping without significant alteration of the motor activity.
体外研究：
This sequence of the C-terminus cyclic region of Urotensin II (U-II) is completely conserved in most species, including in the fish, frog, human, porcine, rat, and mouse, and it is thought to be essential for the agonistic activity of U-II. Urotensin II plays a physiological role in the central nervous system. Intracerebroventricular administration of Urotensin II induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner, as do corticotropin releasing factor (CRF). The effective doses of Urotensin II are 10-100-fold higher than these of CRF in these tests.
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