产品
编 号：F761831
分子式：C24H19NO5
分子量：401.41
分子式：C24H19NO5
分子量：401.41
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CAS No: 959662-26-1
产品详情
生物活性：
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer.
体内研究：
7-Hydroxyneolamellarin A (15 mg/kg; i.v.; 具有 4T1 细胞异种移植物的 BALB/c 小鼠) 抑制体内肿瘤生长。Animal Model:BALB/c mice with 4T1 cells xenografts
Dosage:15 mg/kg
Administration:Intravenous injection; every 2 days for 16 days
Result:Inhibited tumor growth in vivo.
体外研究：
7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela 细胞, MCF-7 细胞和 4T1 细胞) 抑制 HIF-1 信号通路，具有低细胞毒性。7-Hydroxyneolamellarin A (0-100 μM; 12 h) 以剂量依赖性方式降低 Hela 细胞中 VEGF 的 mRNA 水平。7-hydroxyneolamellarin A (0-50 μM; 36 h) 抑制 Hela 细胞迁移、侵袭和增殖。
7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer.
体内研究：
7-Hydroxyneolamellarin A (15 mg/kg; i.v.; 具有 4T1 细胞异种移植物的 BALB/c 小鼠) 抑制体内肿瘤生长。Animal Model:BALB/c mice with 4T1 cells xenografts
Dosage:15 mg/kg
Administration:Intravenous injection; every 2 days for 16 days
Result:Inhibited tumor growth in vivo.
体外研究：
7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela 细胞, MCF-7 细胞和 4T1 细胞) 抑制 HIF-1 信号通路，具有低细胞毒性。7-Hydroxyneolamellarin A (0-100 μM; 12 h) 以剂量依赖性方式降低 Hela 细胞中 VEGF 的 mRNA 水平。7-hydroxyneolamellarin A (0-50 μM; 36 h) 抑制 Hela 细胞迁移、侵袭和增殖。
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