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编 号:F761725
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CAS No: 946415-62-9
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生物活性:
Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer.
体内研究:
Ontuxizumab (50 mg/kg;静脉注射,每天 5 次,连续 5 天) 在人 CD248 敲入小鼠显示抗肿瘤作用。Animal Model:Human CD248 knock-in mice
Dosage:50 mg/kg
Administration:Intravenous injection via tail vein; 50 mg/kg, 5 doses daily for 5 consecutive days
Result:Reduced tumor growth with a lower level of CD248 and α-SMA on neovasculature pericytes.
体外研究:
Ontuxizumab (0-100 μg/mL;12 小时) 诱导 CD248 内化并剂量依赖性地降低了 46% 的人周皮细胞表面的 CD248。