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编 号：F761713
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CAS No: 945781-29-3
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生物活性：
Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis.
体内研究：
Placulumab (0.3、1、3 和 10 mg/kg；腹腔注射；每周两次持续 8 周) 在 Tg197 转基因小鼠模型中具有有效的抗关节炎特性。Placulumab 在食蟹猴中的药代动力学 (PK) 参数RouteDose (mg/kg)Exposure AUC0-336 h (ng.h/mL)Maximum concentration Cmax (ng/mL)Time of maximum concentration tmax (h)Elimination half-life t1/2 (h)Clearance CL (mL/hr/kg)
Intravenous injection (Males)504600000013200000.1671040.985
Intravenous injection (Females)504330000010200000.21197.41.06
RouteDose (mg/kg)Exposure AUC0-336 h (ng.h/mL)Dose normalize exposure AUC0-336 h (norm)Maximum concentration Cmax (ng/mL)Time of maximum concentration tmax (h)Elimination half-life t1/2 (h)
Subcutaneous injection (Males)0.56760001350000319050.0120
Subcutaneous injection (Females)0.5445000890000288048.0108
Subcutaneous injection (Males)539400007880002270040.0117
Subcutaneous injection (Females)538400007670002380012.0109
Subcutaneous injection (Males)504160000083200027200040.0122
Subcutaneous injection (Females)503230000064600021200032.0107
体外研究：
Placulumab (0.01-1000 μg/mL) 对 NS0 细胞和外周血单个核细胞 (PBMC) 具有细胞毒性。
Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis.
体内研究：
Placulumab (0.3、1、3 和 10 mg/kg；腹腔注射；每周两次持续 8 周) 在 Tg197 转基因小鼠模型中具有有效的抗关节炎特性。Placulumab 在食蟹猴中的药代动力学 (PK) 参数RouteDose (mg/kg)Exposure AUC0-336 h (ng.h/mL)Maximum concentration Cmax (ng/mL)Time of maximum concentration tmax (h)Elimination half-life t1/2 (h)Clearance CL (mL/hr/kg)
Intravenous injection (Males)504600000013200000.1671040.985
Intravenous injection (Females)504330000010200000.21197.41.06
RouteDose (mg/kg)Exposure AUC0-336 h (ng.h/mL)Dose normalize exposure AUC0-336 h (norm)Maximum concentration Cmax (ng/mL)Time of maximum concentration tmax (h)Elimination half-life t1/2 (h)
Subcutaneous injection (Males)0.56760001350000319050.0120
Subcutaneous injection (Females)0.5445000890000288048.0108
Subcutaneous injection (Males)539400007880002270040.0117
Subcutaneous injection (Females)538400007670002380012.0109
Subcutaneous injection (Males)504160000083200027200040.0122
Subcutaneous injection (Females)503230000064600021200032.0107
体外研究：
Placulumab (0.01-1000 μg/mL) 对 NS0 细胞和外周血单个核细胞 (PBMC) 具有细胞毒性。
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