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编 号：F761710
分子式：C89H149N33O27S2
分子量：2177.47
分子式：C89H149N33O27S2
分子量：2177.47
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CAS No: 945373-85-3
产品详情
生物活性：
Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma.
体内研究：
Properdistatin (80 mg/kg; 腹腔注射; 每日一次, 持续 4 天) 抑制小鼠黑色素瘤异种移植模型的血管生成并改善血管功能。Animal Model:Adult female BALB/c nu/nu mice (R-18, A-07, and D-12 human melanoma cells)
Dosage:80 mg/kg
Administration:I.p.; daily for 4 days
Result:Inhibited angiogenesis in human melanoma xenografts with low TSP-1 expression, selectively removed small-diameter capillaries, but did not change the morphology of tumor arterioles or tumor venules, and reduced blood supply times and increased plasma velocities.
Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma.
体内研究：
Properdistatin (80 mg/kg; 腹腔注射; 每日一次, 持续 4 天) 抑制小鼠黑色素瘤异种移植模型的血管生成并改善血管功能。Animal Model:Adult female BALB/c nu/nu mice (R-18, A-07, and D-12 human melanoma cells)
Dosage:80 mg/kg
Administration:I.p.; daily for 4 days
Result:Inhibited angiogenesis in human melanoma xenografts with low TSP-1 expression, selectively removed small-diameter capillaries, but did not change the morphology of tumor arterioles or tumor venules, and reduced blood supply times and increased plasma velocities.
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