产品
编 号:F761660
分子式:C16H10ClNO4
分子量:315.71
产品类型
结构图
CAS No: 94205-22-8
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生物活性:
Anticancer agent 93 is a 4-Hydroxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors.
体外研究:
Anticancer agent 93 (compound 4h) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~?50%.Anticancer agent 93 (15 μM; 24-72 h) significantly inhibits A549 cell migration.Anticancer agent 93 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers.