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编 号：F761429
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CAS No: 917121-25-6
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生物活性：
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle.
体内研究：
Topsalysin (肿瘤内注射; 1-10μg /鼠标; 单次剂量) 抑制小鼠的肿瘤生长。Topsalysin (0.35、4.1、25.8 μg/kg, 25 μL; 腹腔注射; 单剂量) 可杀死食蟹猴前列腺注射部位高达 50% 的细胞。Animal Model:Nude mice (6-week-old) subcutaneously bearing tumors
Dosage:0, 1, 5, and 10 μg
Administration:Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days
Result:Showed prostate-specific antigen (PSA)-dependent toxicity in mice.
体外研究：
Topsalysin (19 pM-10 nM; 48 小时) 对 LNCaP, PC3, DU145 和 TSU 细胞显示前列腺特异性抗原 (PSA) 依赖性毒性。
Topsalysin is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle.
体内研究：
Topsalysin (肿瘤内注射; 1-10μg /鼠标; 单次剂量) 抑制小鼠的肿瘤生长。Topsalysin (0.35、4.1、25.8 μg/kg, 25 μL; 腹腔注射; 单剂量) 可杀死食蟹猴前列腺注射部位高达 50% 的细胞。Animal Model:Nude mice (6-week-old) subcutaneously bearing tumors
Dosage:0, 1, 5, and 10 μg
Administration:Intratumor injection; single dose; measured tumor sizes at first day and twice weekly for 28 days
Result:Showed prostate-specific antigen (PSA)-dependent toxicity in mice.
体外研究：
Topsalysin (19 pM-10 nM; 48 小时) 对 LNCaP, PC3, DU145 和 TSU 细胞显示前列腺特异性抗原 (PSA) 依赖性毒性。
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