产品
编 号：F761400
分子式：C100H151N27O29
分子量：2195.44
分子式：C100H151N27O29
分子量：2195.44
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CAS No: 915091-83-7
产品详情
生物活性：
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties.
体内研究：
Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB).Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model.Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory.Animal Model:Wistar rats (200 g)
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Had detectable already 15?min after administration and remained detectable in the blood for at least 24?h.
Animal Model:Wistar rats with multiple sclerosis model (200 g)
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Had no significant effects on the weight changes or the survival of experimental autoimmune encephalomyelitis (EAE) animals.
Animal Model:Old (>18 month) rats and in rats experiencing early stage AD
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Had significantly lower than that of vehicle-treated animals.
体外研究：
Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33?μM.Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells.
Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties.
体内研究：
Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB).Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model.Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory.Animal Model:Wistar rats (200 g)
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Had detectable already 15?min after administration and remained detectable in the blood for at least 24?h.
Animal Model:Wistar rats with multiple sclerosis model (200 g)
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Had no significant effects on the weight changes or the survival of experimental autoimmune encephalomyelitis (EAE) animals.
Animal Model:Old (>18 month) rats and in rats experiencing early stage AD
Dosage:10 mg/kg
Administration:Subcutaneous injection; once
Result:Had significantly lower than that of vehicle-treated animals.
体外研究：
Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33?μM.Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells.
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