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编 号:F761353
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CAS No: 910649-32-0
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生物活性:
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma.
体内研究:
Anrukinzumab (IMA-638; 10 mg/kg; intravenous infusion; single) 减少食蟹猕猴肺部炎症模型中的肺部炎症。Animal Model:Adult male cynomolgus monkeys (6 to 10 kg; cynomolgus monkey model of lung inflammation).
Dosage:10 mg/kg
Administration:Intravenous infusion; single
Result:Reduced total BAL cell count, eosinophil number, and neutrophil number.Reduced the levels of eotaxin and RANTES in BAL fluid.