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编 号：F761307
分子式：C71H111N15O19
分子量：1478.73
分子式：C71H111N15O19
分子量：1478.73
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CAS No: 906547-89-5
产品详情
生物活性：
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF).
体内研究：
Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice.Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001).Animal Model:Ten-week-old male C57BL/6j mice.
Dosage:0.05, 0.2, 0.5 and 5 mg/kg.
Administration:Administered intranasally (i.n.) 15 minutes before HNE (30 UI, i.n.).
Result:Reduced the inflammatory processes of ALI in HNE treated mice.
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF).
体内研究：
Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice.Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001).Animal Model:Ten-week-old male C57BL/6j mice.
Dosage:0.05, 0.2, 0.5 and 5 mg/kg.
Administration:Administered intranasally (i.n.) 15 minutes before HNE (30 UI, i.n.).
Result:Reduced the inflammatory processes of ALI in HNE treated mice.
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